Difference between revisions of "Phosphatase classification"
From PhosphataseWiki
| Line 7: | Line 7: | ||
!bgcolor="#ffffff" rowspan="1" align="center" |Group|| bgcolor="#ffffff" colspan="1" align="center" |Family|| bgcolor="#ffffff" colspan="1" align="center"| Substrate|| bgcolor="#ffffff" colspan="1" align="center"| Present in human | !bgcolor="#ffffff" rowspan="1" align="center" |Group|| bgcolor="#ffffff" colspan="1" align="center" |Family|| bgcolor="#ffffff" colspan="1" align="center"| Substrate|| bgcolor="#ffffff" colspan="1" align="center"| Present in human | ||
|- | |- | ||
| − | |bgcolor="#ffffff" rowspan="4" align="center" |Cys-based Group I|| bgcolor="#ffffff" colspan="1" align="center" |[[Phosphatase_Family_HMWPTP|Classic PTP]]|| bgcolor="#ffffff" colspan="1" align="center"| pTyr || bgcolor="#ffffff" colspan="1" align="center"| Yes | + | |bgcolor="#ffffff" rowspan="4" align="center" |[[Phosphatase_Superfamily_Cys-based_I|Cys-based Group I]]|| bgcolor="#ffffff" colspan="1" align="center" |[[Phosphatase_Family_HMWPTP|Classic PTP]]|| bgcolor="#ffffff" colspan="1" align="center"| pTyr || bgcolor="#ffffff" colspan="1" align="center"| Yes |
|- | |- | ||
| bgcolor="#ffffff" colspan="1" align="center" |[[Phosphatase_Family_DSP_PTEN|DSP and PTEN]]|| bgcolor="#ffffff" colspan="1" align="center"| pTyr, pSer/pThr, lipid || bgcolor="#ffffff" colspan="1" align="center"| Yes | | bgcolor="#ffffff" colspan="1" align="center" |[[Phosphatase_Family_DSP_PTEN|DSP and PTEN]]|| bgcolor="#ffffff" colspan="1" align="center"| pTyr, pSer/pThr, lipid || bgcolor="#ffffff" colspan="1" align="center"| Yes | ||
| Line 15: | Line 15: | ||
| bgcolor="#ffffff" colspan="1" align="center" |[[Phosphatase_Family_OCA|OCA]]|| bgcolor="#ffffff" colspan="1" align="center"| ? || bgcolor="#ffffff" colspan="1" align="center"| No | | bgcolor="#ffffff" colspan="1" align="center" |[[Phosphatase_Family_OCA|OCA]]|| bgcolor="#ffffff" colspan="1" align="center"| ? || bgcolor="#ffffff" colspan="1" align="center"| No | ||
|- | |- | ||
| − | |bgcolor="#ffffff" rowspan="1" align="center" |Cys-based Group II|| bgcolor="#ffffff" colspan="1" align="center" |[[Phosphatase_Family_CDC25|CDC25]]|| bgcolor="#ffffff" colspan="1" align="center"| pTyr, pThr || bgcolor="#ffffff" colspan="1" align="center"| Yes | + | |bgcolor="#ffffff" rowspan="1" align="center" |[[Phosphatase_Superfamily_Cys-based_II|Cys-based Group II]]|| bgcolor="#ffffff" colspan="1" align="center" |[[Phosphatase_Family_CDC25|CDC25]]|| bgcolor="#ffffff" colspan="1" align="center"| pTyr, pThr || bgcolor="#ffffff" colspan="1" align="center"| Yes |
|- | |- | ||
|bgcolor="#ffffff" rowspan="3" align="center" |[[Phosphatase_Superfamily_Cys-based_III|Cys-based Group III]]|| bgcolor="#ffffff" colspan="1" align="center" |[[Phosphatase_Family_LMWPTP|LMWPTP]]|| bgcolor="#ffffff" colspan="1" align="center"| pTyr || bgcolor="#ffffff" colspan="1" align="center"| Yes | |bgcolor="#ffffff" rowspan="3" align="center" |[[Phosphatase_Superfamily_Cys-based_III|Cys-based Group III]]|| bgcolor="#ffffff" colspan="1" align="center" |[[Phosphatase_Family_LMWPTP|LMWPTP]]|| bgcolor="#ffffff" colspan="1" align="center"| pTyr || bgcolor="#ffffff" colspan="1" align="center"| Yes | ||
Revision as of 20:19, 2 May 2014
Phosphatases were first clustered by sequence similarity in the phosphatase domain, and additional information from domains outside of the catalytic domain, from evolutionary conservation, and from known functions was added. The result is a hybrid classification, in which no criterion is universally satisfied, but aims to be of practical use to a range of phosphatase interests. The classification grows as new phosphatomes are sequenced.
Classification Chart
| Group | Family | Substrate | Present in human |
|---|---|---|---|
| Cys-based Group I | Classic PTP | pTyr | Yes |
| DSP and PTEN | pTyr, pSer/pThr, lipid | Yes | |
| Myotubularin | lipid | Yes | |
| OCA | ? | No | |
| Cys-based Group II | CDC25 | pTyr, pThr | Yes |
| Cys-based Group III | LMWPTP | pTyr | Yes |
| SSU72 | pSer | Yes | |
| ArsC | Arsenate | No | |
| HAD | EYA | pTyr | Yes |
| FCP | pSer | Yes | |
| NagD | pTyr, pSer | Yes | |
| MDP1 | pTyr? | Yes | |
| PPP | PPP | pSer/pThr | Yes |
| PPM | PPM | pSer/pThr | Yes |
| PHP | PHP | pHis | Yes |
| RTR1 | RTR1 | pSer | Yes |
