Difference between revisions of "Phosphatase classification"
From PhosphataseWiki
(→Other phosphatases) |
|||
Line 40: | Line 40: | ||
|} | |} | ||
− | == [[other_phosphatase|Other | + | == [[other_phosphatase|Other Phosphatases]] == |
== [[Other_Classification_Schemes|Other Classification Schemes]] == | == [[Other_Classification_Schemes|Other Classification Schemes]] == |
Revision as of 04:16, 9 May 2014
Phosphatases were first clustered by sequence similarity in the phosphatase domain, and additional information from domains outside of the catalytic domain, from evolutionary conservation, and from known functions was added. The result is a hybrid classification, in which no criterion is universally satisfied, but aims to be of practical use to a range of phosphatase interests. The classification grows as new phosphatomes are sequenced.
Classification Chart
Group | Family | Substrate | Present in human |
---|---|---|---|
Cys-based Group I | Classic PTP | pTyr | Yes |
DSP and PTEN | pTyr, pSer/pThr, lipid | Yes | |
Myotubularin | lipid | Yes | |
OCA | ? | No | |
Cys-based Group II | CDC25 | pTyr, pThr | Yes |
Cys-based Group III | LMWPTP | pTyr | Yes |
SSU72 | pSer | Yes | |
ArsC | Arsenate | No | |
HAD | EYA | pTyr | Yes |
FCP | pSer | Yes | |
NagD | pTyr, pSer | Yes | |
MDP1 | pTyr? | Yes | |
PPP | PPP | pSer/pThr | Yes |
PPM | PPM | pSer/pThr | Yes |
PHP | PHP | pHis | Yes |
RTR1 | RTR1 | pSer | Yes |