Difference between revisions of "Phosphatase classification"
From PhosphataseWiki
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|bgcolor="#ffffff" rowspan="1" align="center" |[[Phosphatase_Superfamily_PPP|Metallo-dependent phosphatases]]|| bgcolor="#ffffff" colspan="1" align="center" |[[Phosphatase_Family_PPP|PPP]]|| bgcolor="#ffffff" colspan="1" align="center"| pSer/pThr || bgcolor="#ffffff" colspan="1" align="center"| Yes | |bgcolor="#ffffff" rowspan="1" align="center" |[[Phosphatase_Superfamily_PPP|Metallo-dependent phosphatases]]|| bgcolor="#ffffff" colspan="1" align="center" |[[Phosphatase_Family_PPP|PPP]]|| bgcolor="#ffffff" colspan="1" align="center"| pSer/pThr || bgcolor="#ffffff" colspan="1" align="center"| Yes | ||
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| − | |bgcolor="#ffffff" rowspan="1" align="center" |[[Phosphatase_Superfamily_PPM|PPM]] ( | + | |bgcolor="#ffffff" rowspan="1" align="center" |[[Phosphatase_Superfamily_PPM|PPM]] (PP2C)|| bgcolor="#ffffff" colspan="1" align="center" |[[Phosphatase_Family_PPM|PPM]]|| bgcolor="#ffffff" colspan="1" align="center"| pSer/pThr || bgcolor="#ffffff" colspan="1" align="center"| Yes |
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|bgcolor="#ffffff" rowspan="1" align="center" |[[Phosphatase_Superfamily_PHP|PHP]]|| bgcolor="#ffffff" colspan="1" align="center" |[[Phosphatase_Family_PHP|PHP]]|| bgcolor="#ffffff" colspan="1" align="center"| pHis || bgcolor="#ffffff" colspan="1" align="center"| Yes | |bgcolor="#ffffff" rowspan="1" align="center" |[[Phosphatase_Superfamily_PHP|PHP]]|| bgcolor="#ffffff" colspan="1" align="center" |[[Phosphatase_Family_PHP|PHP]]|| bgcolor="#ffffff" colspan="1" align="center"| pHis || bgcolor="#ffffff" colspan="1" align="center"| Yes | ||
Revision as of 23:49, 27 May 2014
Phosphatases were first clustered by sequence similarity in the phosphatase domain, and additional information from domains outside of the catalytic domain, from evolutionary conservation, and from known functions was added. The result is a hybrid classification, in which no criterion is universally satisfied, but aims to be of practical use to a range of phosphatase interests. The classification grows as new phosphatomes are sequenced.
Classification Chart
| Superfamily | Family | Substrate | Present in human |
|---|---|---|---|
| Cys-based Group I | Classic PTP | pTyr | Yes |
| DSP and PTEN | pTyr, pSer/pThr, lipid | Yes | |
| Myotubularin | lipid | Yes | |
| OCA | ? | No | |
| Cys-based Group II (Rhondanese) | CDC25 | pTyr, pThr | Yes |
| Cys-based Group III | LMWPTP | pTyr | Yes |
| SSU72 | pSer | Yes | |
| ArsC | Arsenate | No | |
| HAD | EYA | pTyr | Yes |
| FCP | pSer | Yes | |
| NagD | pTyr, pSer | Yes | |
| MDP1 | pTyr? | Yes | |
| Metallo-dependent phosphatases | PPP | pSer/pThr | Yes |
| PPM (PP2C) | PPM | pSer/pThr | Yes |
| PHP | PHP | pHis | Yes |
| RTR1 | RTR1 | pSer | Yes |
