Difference between revisions of "Phosphatase classification"
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Phosphatases were first clustered by sequence similarity in the phosphatase domain, and additional information from domains outside of the catalytic domain, from evolutionary conservation, and from known functions was added. The result is a hybrid classification, in which no criterion is universally satisfied, but aims to be of practical use to a range of phosphatase interests. The classification grows as new phosphatomes are sequenced. | Phosphatases were first clustered by sequence similarity in the phosphatase domain, and additional information from domains outside of the catalytic domain, from evolutionary conservation, and from known functions was added. The result is a hybrid classification, in which no criterion is universally satisfied, but aims to be of practical use to a range of phosphatase interests. The classification grows as new phosphatomes are sequenced. | ||
| − | == Classification Chart == | + | == Classification Chart of Protein Phosphatases == |
{| class="wikitable" border="2" style="background: #ffffff; border: 1px #000000 solid; border-collapse: collapse; font-size: 100%;" cellpadding="5" cellspacing="10" | {| class="wikitable" border="2" style="background: #ffffff; border: 1px #000000 solid; border-collapse: collapse; font-size: 100%;" cellpadding="5" cellspacing="10" | ||
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|bgcolor="#ffffff" rowspan="1" |[[Phosphatase_Superfamily_Cys-based_II|Cys-based III]] (Rhondanese)|| bgcolor="#ffffff" colspan="1" |[[Phosphatase_Family_CDC25|CDC25]]|| bgcolor="#ffffff" colspan="1" | pTyr, pThr || bgcolor="#ffffff" colspan="1" | Yes | |bgcolor="#ffffff" rowspan="1" |[[Phosphatase_Superfamily_Cys-based_II|Cys-based III]] (Rhondanese)|| bgcolor="#ffffff" colspan="1" |[[Phosphatase_Family_CDC25|CDC25]]|| bgcolor="#ffffff" colspan="1" | pTyr, pThr || bgcolor="#ffffff" colspan="1" | Yes | ||
|- | |- | ||
| − | |bgcolor="#ffffff" rowspan=" | + | |bgcolor="#ffffff" rowspan="3" |[[Phosphatase_Group_HAD|HAD]]|| bgcolor="#ffffff" colspan="1" |[[Phosphatase_Family_EYA|EYA]]|| bgcolor="#ffffff" colspan="1" | pTyr || bgcolor="#ffffff" colspan="1" | Yes |
|- | |- | ||
|bgcolor="#ffffff" colspan="1" |[[Phosphatase_Family_FCP|FCP]]|| bgcolor="#ffffff" colspan="1" | pSer || bgcolor="#ffffff" colspan="1" | Yes | |bgcolor="#ffffff" colspan="1" |[[Phosphatase_Family_FCP|FCP]]|| bgcolor="#ffffff" colspan="1" | pSer || bgcolor="#ffffff" colspan="1" | Yes | ||
|- | |- | ||
|bgcolor="#ffffff" colspan="1" |[[Phosphatase_Family_NagD|NagD]]|| bgcolor="#ffffff" colspan="1" | pTyr, pSer || bgcolor="#ffffff" colspan="1" | Yes | |bgcolor="#ffffff" colspan="1" |[[Phosphatase_Family_NagD|NagD]]|| bgcolor="#ffffff" colspan="1" | pTyr, pSer || bgcolor="#ffffff" colspan="1" | Yes | ||
| − | |||
| − | |||
|- | |- | ||
|bgcolor="#ffffff" rowspan="1" |[[Phosphatase_Superfamily_PPP|Metallo-dependent phosphatases]]|| bgcolor="#ffffff" colspan="1" |[[Phosphatase_Family_PPP|PPP]]|| bgcolor="#ffffff" colspan="1" | pSer/pThr || bgcolor="#ffffff" colspan="1" | Yes | |bgcolor="#ffffff" rowspan="1" |[[Phosphatase_Superfamily_PPP|Metallo-dependent phosphatases]]|| bgcolor="#ffffff" colspan="1" |[[Phosphatase_Family_PPP|PPP]]|| bgcolor="#ffffff" colspan="1" | pSer/pThr || bgcolor="#ffffff" colspan="1" | Yes | ||
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|bgcolor="#ffffff" rowspan="1" |[[Phosphatase_Superfamily_RTR1|RTR1]]|| bgcolor="#ffffff" colspan="1" |[[Phosphatase_Family_RTR1|RTR1]]|| bgcolor="#ffffff" colspan="1" | pSer || bgcolor="#ffffff" colspan="1" | Yes | |bgcolor="#ffffff" rowspan="1" |[[Phosphatase_Superfamily_RTR1|RTR1]]|| bgcolor="#ffffff" colspan="1" |[[Phosphatase_Family_RTR1|RTR1]]|| bgcolor="#ffffff" colspan="1" | pSer || bgcolor="#ffffff" colspan="1" | Yes | ||
|} | |} | ||
| + | |||
| + | == [[Unclassified_phosphatases|Unclassified Phosphatases]] == | ||
== [[other_phosphatase|Other Phosphatases]] (obsolete) == | == [[other_phosphatase|Other Phosphatases]] (obsolete) == | ||
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| − | |||
== [[Other_Classification_Schemes|Other Classification Schemes]] == | == [[Other_Classification_Schemes|Other Classification Schemes]] == | ||
Revision as of 16:33, 17 June 2014
Phosphatases were first clustered by sequence similarity in the phosphatase domain, and additional information from domains outside of the catalytic domain, from evolutionary conservation, and from known functions was added. The result is a hybrid classification, in which no criterion is universally satisfied, but aims to be of practical use to a range of phosphatase interests. The classification grows as new phosphatomes are sequenced.
Contents
Classification Chart of Protein Phosphatases
| Superfamily | Family | Substrate | Present in human |
|---|---|---|---|
| Cys-based I | Classic PTP | pTyr | Yes |
| DSP and PTEN | pTyr, pSer/pThr, lipid | Yes | |
| Myotubularin | lipid | Yes | |
| OCA | ? | No | |
| Cys-based II | LMWPTP | pTyr | Yes |
| SSU72 | pSer | Yes | |
| ArsC | Arsenate | No | |
| Cys-based III (Rhondanese) | CDC25 | pTyr, pThr | Yes |
| HAD | EYA | pTyr | Yes |
| FCP | pSer | Yes | |
| NagD | pTyr, pSer | Yes | |
| Metallo-dependent phosphatases | PPP | pSer/pThr | Yes |
| PPM (PP2C) | PPM | pSer/pThr | Yes |
| Alkaline Phosphatase | Alkaline Phosphatase | Yes | |
| Histidine Phosphatase | HP, branch 1 | pTyr, pSer/pThr | Yes |
| HP, branch 2 | pTyr | Yes | |
| PHP | PHP | pHis | Yes |
| RTR1 | RTR1 | pSer | Yes |
