Difference between revisions of "Phosphatase classification"

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(Classification Chart)
(Classification Chart)
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|bgcolor="#ffffff" rowspan="1"  |[[Phosphatase_Superfamily_Alkaline_Phosphatase|Alkaline Phosphatase]]|| bgcolor="#ffffff" colspan="1"  |[[Phosphatase_Family_Alkaline_Phosphatase|Alkaline Phosphatase]]|| bgcolor="#ffffff" colspan="1" |  || bgcolor="#ffffff" colspan="1" | Yes
 
|bgcolor="#ffffff" rowspan="1"  |[[Phosphatase_Superfamily_Alkaline_Phosphatase|Alkaline Phosphatase]]|| bgcolor="#ffffff" colspan="1"  |[[Phosphatase_Family_Alkaline_Phosphatase|Alkaline Phosphatase]]|| bgcolor="#ffffff" colspan="1" |  || bgcolor="#ffffff" colspan="1" | Yes
 
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|bgcolor="#ffffff" rowspan="2"  |[[Phosphatase_Superfamily_Histidine_Phosphatase|Histidine Phosphatase]]|| bgcolor="#ffffff" colspan="1"  |[[Phosphatase_Family_Histidine_Phosphatase_Branch1|HP, branch 1]]|| bgcolor="#ffffff" colspan="1" | || bgcolor="#ffffff" colspan="1" | Yes
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|bgcolor="#ffffff" rowspan="2"  |[[Phosphatase_Superfamily_Histidine_Phosphatase|Histidine Phosphatase]]|| bgcolor="#ffffff" colspan="1"  |[[Phosphatase_Family_Histidine_Phosphatase_Branch1|HP, branch 1]]|| bgcolor="#ffffff" colspan="1" | pTyr, pSer/pThr || bgcolor="#ffffff" colspan="1" | Yes
 
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|-
| bgcolor="#ffffff" colspan="1"  |[[Phosphatase_Family_Histidine_Phosphatase_Branch2|HP, branch 2]]|| bgcolor="#ffffff" colspan="1" | || bgcolor="#ffffff" colspan="1" | Yes
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| bgcolor="#ffffff" colspan="1"  |[[Phosphatase_Family_Histidine_Phosphatase_Branch2|HP, branch 2]]|| bgcolor="#ffffff" colspan="1" | pTyr || bgcolor="#ffffff" colspan="1" | Yes
 
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|bgcolor="#ffffff" rowspan="1"  |[[Phosphatase_Superfamily_PHP|PHP]]|| bgcolor="#ffffff" colspan="1"  |[[Phosphatase_Family_PHP|PHP]]|| bgcolor="#ffffff" colspan="1" | pHis || bgcolor="#ffffff" colspan="1" | Yes
 
|bgcolor="#ffffff" rowspan="1"  |[[Phosphatase_Superfamily_PHP|PHP]]|| bgcolor="#ffffff" colspan="1"  |[[Phosphatase_Family_PHP|PHP]]|| bgcolor="#ffffff" colspan="1" | pHis || bgcolor="#ffffff" colspan="1" | Yes

Revision as of 16:29, 17 June 2014

Phosphatases were first clustered by sequence similarity in the phosphatase domain, and additional information from domains outside of the catalytic domain, from evolutionary conservation, and from known functions was added. The result is a hybrid classification, in which no criterion is universally satisfied, but aims to be of practical use to a range of phosphatase interests. The classification grows as new phosphatomes are sequenced.

Classification Chart

Superfamily Family Substrate Present in human
Cys-based I Classic PTP pTyr Yes
DSP and PTEN pTyr, pSer/pThr, lipid Yes
Myotubularin lipid Yes
OCA  ? No
Cys-based II LMWPTP pTyr Yes
SSU72 pSer Yes
ArsC Arsenate No
Cys-based III (Rhondanese) CDC25 pTyr, pThr Yes
HAD EYA pTyr Yes
FCP pSer Yes
NagD pTyr, pSer Yes
MDP1 pTyr? Yes
Metallo-dependent phosphatases PPP pSer/pThr Yes
PPM (PP2C) PPM pSer/pThr Yes
Alkaline Phosphatase Alkaline Phosphatase Yes
Histidine Phosphatase HP, branch 1 pTyr, pSer/pThr Yes
HP, branch 2 pTyr Yes
PHP PHP pHis Yes
RTR1 RTR1 pSer Yes

Other Phosphatases

Unclassified Phosphatases

Other Classification Schemes