Difference between revisions of "Phosphatase classification"
From PhosphataseWiki
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|bgcolor="#ffffff" colspan="1" |[[Phosphatase_Family_PAP|PAP]] (purple acid phosphatase)|| bgcolor="#ffffff" colspan="1" | ? || bgcolor="#ffffff" colspan="1" | Yes | |bgcolor="#ffffff" colspan="1" |[[Phosphatase_Family_PAP|PAP]] (purple acid phosphatase)|| bgcolor="#ffffff" colspan="1" | ? || bgcolor="#ffffff" colspan="1" | Yes | ||
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| − | |bgcolor="#ffffff" rowspan="1" |[[Phosphatase_Fold_PPM|PPM]]||bgcolor="#ffffff" rowspan="1" |[[Phosphatase_Superfamily_PPM|PPM]] | + | |bgcolor="#ffffff" rowspan="1" |[[Phosphatase_Fold_PPM|PPM/PP2C]]||bgcolor="#ffffff" rowspan="1" |[[Phosphatase_Superfamily_PPM|PPM/PP2C]]|| bgcolor="#ffffff" colspan="1" |[[Phosphatase_Family_PPM|PPM/PP2C]]|| bgcolor="#ffffff" colspan="1" | pSer/pThr || bgcolor="#ffffff" colspan="1" | Yes |
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|bgcolor="#ffffff" rowspan="1" |[[Phosphatase_Fold_AP|AP]]||bgcolor="#ffffff" rowspan="1" |[[Phosphatase_Superfamily_AP|AP]] (Alkaline Phosphatase)|| bgcolor="#ffffff" colspan="1" |[[Phosphatase_Family_AP|AP]]|| bgcolor="#ffffff" colspan="1" | pTyr, perhaps pSer/pThr || bgcolor="#ffffff" colspan="1" | Yes | |bgcolor="#ffffff" rowspan="1" |[[Phosphatase_Fold_AP|AP]]||bgcolor="#ffffff" rowspan="1" |[[Phosphatase_Superfamily_AP|AP]] (Alkaline Phosphatase)|| bgcolor="#ffffff" colspan="1" |[[Phosphatase_Family_AP|AP]]|| bgcolor="#ffffff" colspan="1" | pTyr, perhaps pSer/pThr || bgcolor="#ffffff" colspan="1" | Yes | ||
Revision as of 16:18, 5 January 2015
Phosphatases were first clustered by sequence similarity in the phosphatase domain, and additional information from domains outside of the catalytic domain, from evolutionary conservation, and from known functions was added. The result is a hybrid classification, in which no criterion is universally satisfied, but aims to be of practical use to a range of phosphatase interests. The classification grows as new phosphatomes are sequenced.
Classification Chart of Protein Phosphatases
| Fold | Superfamily | Family | Substrate | Present in human |
|---|---|---|---|---|
| CC1 | CC1 (Cystine-based group 1) | Classic PTP | pTyr | Yes |
| DSP | pTyr, pSer/pThr, small molecule | Yes | ||
| PTEN | lipid | Yes | ||
| Myotubularin | lipid | Yes | ||
| OCA | ? | No | ||
| CC2 | CC2 (Cysteine Based Group 2) | LMWPTP | pTyr | Yes |
| SSU72 | pSer | Yes | ||
| ArsC | Arsenate | No | ||
| CC3 | CC3 (Rhodanese) | CDC25 | pTyr, pThr | Yes |
| HAD | HAD | EYA | pTyr | Yes |
| FCP | pSer | Yes | ||
| NagD | pTyr, pSer | Yes | ||
| MTDP | MTDP (MeTallo-Dependent Phosphatases) | PPP | pSer/pThr | Yes |
| PAP (purple acid phosphatase) | ? | Yes | ||
| PPM/PP2C | PPM/PP2C | PPM/PP2C | pSer/pThr | Yes |
| AP | AP (Alkaline Phosphatase) | AP | pTyr, perhaps pSer/pThr | Yes |
| HP | HP (Histidine Phosphatase) | HP, branch 1 | pTyr, pSer/pThr | Yes |
| HP, branch 2 | pTyr | Yes | ||
| PHP | PHP | PHP | pHis | Yes |
| RTR1 | RTR1 | RTR1 | pSer | Yes |
