Difference between revisions of "Phosphatase classification"
From PhosphataseWiki
(→Classification Chart of Protein Phosphatases) |
(→Classification Chart of Protein Phosphatases) |
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!bgcolor="#ffffff" rowspan="1" |Fold||bgcolor="#ffffff" rowspan="1" |Superfamily|| bgcolor="#ffffff" colspan="1" |Family|| bgcolor="#ffffff" colspan="1" | Substrate|| bgcolor="#ffffff" colspan="1" | Present in human | !bgcolor="#ffffff" rowspan="1" |Fold||bgcolor="#ffffff" rowspan="1" |Superfamily|| bgcolor="#ffffff" colspan="1" |Family|| bgcolor="#ffffff" colspan="1" | Substrate|| bgcolor="#ffffff" colspan="1" | Present in human | ||
|- | |- | ||
| − | |bgcolor="#ffffff" rowspan="7" |[[Phosphatase_Fold_CC1|CC1]]||bgcolor="#ffffff" rowspan="7" |[[Phosphatase_Superfamily_CC1|CC1]] | + | |bgcolor="#ffffff" rowspan="7" |
| + | | [[Phosphatase_Fold_CC1|CC1]]||bgcolor="#ffffff" rowspan="7" | ||
| + | | [[Phosphatase_Superfamily_CC1|CC1]] || bgcolor="#ffffff" colspan="1" | ||
| + | | [[Phosphatase_Family_PTP|PTP]]|| bgcolor="#ffffff" colspan="1" | ||
| + | | pTyr | ||
| + | | | ||
| + | | bgcolor="#ffffff" colspan="1" | Yes | ||
|- | |- | ||
| bgcolor="#ffffff" colspan="1" |[[Phosphatase_Family_DSP|DSP]]|| bgcolor="#ffffff" colspan="1" | pTyr, pSer/pThr, small molecule || bgcolor="#ffffff" colspan="1" | Yes | | bgcolor="#ffffff" colspan="1" |[[Phosphatase_Family_DSP|DSP]]|| bgcolor="#ffffff" colspan="1" | pTyr, pSer/pThr, small molecule || bgcolor="#ffffff" colspan="1" | Yes | ||
| Line 21: | Line 27: | ||
| bgcolor="#ffffff" colspan="1" |[[Phosphatase_Family_OCA|OCA]]|| bgcolor="#ffffff" colspan="1" | ? || bgcolor="#ffffff" colspan="1" | No | | bgcolor="#ffffff" colspan="1" |[[Phosphatase_Family_OCA|OCA]]|| bgcolor="#ffffff" colspan="1" | ? || bgcolor="#ffffff" colspan="1" | No | ||
|- | |- | ||
| − | |bgcolor="#ffffff" rowspan="3" |[[Phosphatase_Fold_CC2|CC2]]||bgcolor="#ffffff" rowspan="3" |[[Phosphatase_Superfamily_CC2|CC2]] | + | |bgcolor="#ffffff" rowspan="3" |[[Phosphatase_Fold_CC2|CC2]]||bgcolor="#ffffff" rowspan="3" |[[Phosphatase_Superfamily_CC2|CC2]] || bgcolor="#ffffff" colspan="1" |[[Phosphatase_Family_LMWPTP|LMWPTP]]|| bgcolor="#ffffff" colspan="1" | pTyr || bgcolor="#ffffff" colspan="1" | Yes |
|- | |- | ||
| bgcolor="#ffffff" colspan="1" |[[Phosphatase_Family_SSU72|SSU72]]|| bgcolor="#ffffff" colspan="1" | pSer || bgcolor="#ffffff" colspan="1" | Yes | | bgcolor="#ffffff" colspan="1" |[[Phosphatase_Family_SSU72|SSU72]]|| bgcolor="#ffffff" colspan="1" | pSer || bgcolor="#ffffff" colspan="1" | Yes | ||
| Line 27: | Line 33: | ||
| bgcolor="#ffffff" colspan="1" |[[Phosphatase_Family_ArsC|ArsC]]|| bgcolor="#ffffff" colspan="1" | Arsenate || bgcolor="#ffffff" colspan="1" | No | | bgcolor="#ffffff" colspan="1" |[[Phosphatase_Family_ArsC|ArsC]]|| bgcolor="#ffffff" colspan="1" | Arsenate || bgcolor="#ffffff" colspan="1" | No | ||
|- | |- | ||
| − | |bgcolor="#ffffff" rowspan="1" |[[Phosphatase_Fold_Rhodanese|CC3]]||bgcolor="#ffffff" rowspan="1" |[[Phosphatase_Superfamily_CC3|CC3]] | + | |bgcolor="#ffffff" rowspan="1" |[[Phosphatase_Fold_Rhodanese|CC3]]||bgcolor="#ffffff" rowspan="1" |[[Phosphatase_Superfamily_CC3|CC3/Rhodanese]]|| bgcolor="#ffffff" colspan="1" |[[Phosphatase_Family_CDC25|CDC25]]|| bgcolor="#ffffff" colspan="1" | pTyr, pThr || bgcolor="#ffffff" colspan="1" | Yes |
|- | |- | ||
|bgcolor="#ffffff" rowspan="3" |[[Phosphatase_Group_HAD|HAD]]||bgcolor="#ffffff" rowspan="3" |[[Phosphatase_Group_HAD|HAD]]|| bgcolor="#ffffff" colspan="1" |[[Phosphatase_Family_EYA|EYA]]|| bgcolor="#ffffff" colspan="1" | pTyr || bgcolor="#ffffff" colspan="1" | Yes | |bgcolor="#ffffff" rowspan="3" |[[Phosphatase_Group_HAD|HAD]]||bgcolor="#ffffff" rowspan="3" |[[Phosphatase_Group_HAD|HAD]]|| bgcolor="#ffffff" colspan="1" |[[Phosphatase_Family_EYA|EYA]]|| bgcolor="#ffffff" colspan="1" | pTyr || bgcolor="#ffffff" colspan="1" | Yes | ||
| Line 35: | Line 41: | ||
|bgcolor="#ffffff" colspan="1" |[[Phosphatase_Family_NagD|NagD]]|| bgcolor="#ffffff" colspan="1" | pTyr, pSer || bgcolor="#ffffff" colspan="1" | Yes | |bgcolor="#ffffff" colspan="1" |[[Phosphatase_Family_NagD|NagD]]|| bgcolor="#ffffff" colspan="1" | pTyr, pSer || bgcolor="#ffffff" colspan="1" | Yes | ||
|- | |- | ||
| − | |bgcolor="#ffffff" rowspan="2" |[[Phosphatase_Fold_MTDP|MTDP]]||bgcolor="#ffffff" rowspan="2" |[[Phosphatase_Superfamily_MTDP|MTDP]] | + | |bgcolor="#ffffff" rowspan="2" |[[Phosphatase_Fold_MTDP|MTDP]]||bgcolor="#ffffff" rowspan="2" |[[Phosphatase_Superfamily_MTDP|MTDP]] || bgcolor="#ffffff" colspan="1" |[[Phosphatase_Family_PPP|PPP]]|| bgcolor="#ffffff" colspan="1" | pSer/pThr || bgcolor="#ffffff" colspan="1" | Yes |
|- | |- | ||
| − | |bgcolor="#ffffff" colspan="1" |[[Phosphatase_Family_PAP|PAP]] | + | |bgcolor="#ffffff" colspan="1" |[[Phosphatase_Family_PAP|PAP]] || bgcolor="#ffffff" colspan="1" | ? || bgcolor="#ffffff" colspan="1" | Yes |
|- | |- | ||
|bgcolor="#ffffff" rowspan="1" |[[Phosphatase_Fold_PPM|PPM/PP2C]]||bgcolor="#ffffff" rowspan="1" |[[Phosphatase_Superfamily_PPM|PPM/PP2C]]|| bgcolor="#ffffff" colspan="1" |[[Phosphatase_Family_PPM|PPM/PP2C]]|| bgcolor="#ffffff" colspan="1" | pSer/pThr || bgcolor="#ffffff" colspan="1" | Yes | |bgcolor="#ffffff" rowspan="1" |[[Phosphatase_Fold_PPM|PPM/PP2C]]||bgcolor="#ffffff" rowspan="1" |[[Phosphatase_Superfamily_PPM|PPM/PP2C]]|| bgcolor="#ffffff" colspan="1" |[[Phosphatase_Family_PPM|PPM/PP2C]]|| bgcolor="#ffffff" colspan="1" | pSer/pThr || bgcolor="#ffffff" colspan="1" | Yes | ||
|- | |- | ||
| − | |bgcolor="#ffffff" rowspan="1" |[[Phosphatase_Fold_AP|AP]]||bgcolor="#ffffff" rowspan="1" |[[Phosphatase_Superfamily_AP|AP]] | + | |bgcolor="#ffffff" rowspan="1" |[[Phosphatase_Fold_AP|AP]]||bgcolor="#ffffff" rowspan="1" |[[Phosphatase_Superfamily_AP|AP]] || bgcolor="#ffffff" colspan="1" |[[Phosphatase_Family_AP|AP]]|| bgcolor="#ffffff" colspan="1" | pTyr, perhaps pSer/pThr || bgcolor="#ffffff" colspan="1" | Yes |
|- | |- | ||
| − | |bgcolor="#ffffff" rowspan="2" |[[Phosphatase_Fold_HP|HP]]||bgcolor="#ffffff" rowspan="2" |[[Phosphatase_Superfamily_HP|HP]] | + | |bgcolor="#ffffff" rowspan="2" |[[Phosphatase_Fold_HP|HP]]||bgcolor="#ffffff" rowspan="2" |[[Phosphatase_Superfamily_HP|HP]] || bgcolor="#ffffff" colspan="1" |[[Phosphatase_Family_HP1|HP, branch 1]]|| bgcolor="#ffffff" colspan="1" | pTyr, pSer/pThr || bgcolor="#ffffff" colspan="1" | Yes |
|- | |- | ||
| bgcolor="#ffffff" colspan="1" |[[Phosphatase_Family_HP2|HP, branch 2]]|| bgcolor="#ffffff" colspan="1" | pTyr || bgcolor="#ffffff" colspan="1" | Yes | | bgcolor="#ffffff" colspan="1" |[[Phosphatase_Family_HP2|HP, branch 2]]|| bgcolor="#ffffff" colspan="1" | pTyr || bgcolor="#ffffff" colspan="1" | Yes | ||
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|bgcolor="#ffffff" rowspan="1" |[[Phosphatase_Fold_RTR1|RTR1]]||bgcolor="#ffffff" rowspan="1" |[[Phosphatase_Superfamily_RTR1|RTR1]]|| bgcolor="#ffffff" colspan="1" |[[Phosphatase_Family_RTR1|RTR1]]|| bgcolor="#ffffff" colspan="1" | pSer || bgcolor="#ffffff" colspan="1" | Yes | |bgcolor="#ffffff" rowspan="1" |[[Phosphatase_Fold_RTR1|RTR1]]||bgcolor="#ffffff" rowspan="1" |[[Phosphatase_Superfamily_RTR1|RTR1]]|| bgcolor="#ffffff" colspan="1" |[[Phosphatase_Family_RTR1|RTR1]]|| bgcolor="#ffffff" colspan="1" | pSer || bgcolor="#ffffff" colspan="1" | Yes | ||
|} | |} | ||
| + | |||
| + | Abbreviations: CC1, Cysteine-based Class I; CC2, Cysteine-based Class II; CC3, Cysteine-based Class III; MTDP, MeTallo-Dependent Phosphatase; PAP, Purple Acid Phosphatase; AP, Alkaline Phosphatase; HP, Histidine Phosphatase. | ||
== [[Non-protein_phosphatases|Non-protein phosphatases]] == | == [[Non-protein_phosphatases|Non-protein phosphatases]] == | ||
== [[Other_Classification_Schemes|Other Classification Schemes]] == | == [[Other_Classification_Schemes|Other Classification Schemes]] == | ||
Revision as of 23:29, 1 June 2015
Phosphatases were first clustered by sequence similarity in the phosphatase domain, and additional information from domains outside of the catalytic domain, from evolutionary conservation, and from known functions was added. The result is a hybrid classification, in which no criterion is universally satisfied, but aims to be of practical use to a range of phosphatase interests. The classification grows as new phosphatomes are sequenced.
Classification Chart of Protein Phosphatases
| Fold | Superfamily | Family | Substrate | Present in human | |||||
|---|---|---|---|---|---|---|---|---|---|
| bgcolor="#ffffff" rowspan="7" | CC1 | bgcolor="#ffffff" rowspan="7" | CC1 | bgcolor="#ffffff" colspan="1" | PTP | bgcolor="#ffffff" colspan="1" | pTyr | Yes | |
| DSP | pTyr, pSer/pThr, small molecule | Yes | |||||||
| PTEN | lipid | Yes | |||||||
| Myotubularin | lipid | Yes | |||||||
| SAC | lipid | Yes | |||||||
| Paladin | inactive | Yes | |||||||
| OCA | ? | No | |||||||
| CC2 | CC2 | LMWPTP | pTyr | Yes | |||||
| SSU72 | pSer | Yes | |||||||
| ArsC | Arsenate | No | |||||||
| CC3 | CC3/Rhodanese | CDC25 | pTyr, pThr | Yes | |||||
| HAD | HAD | EYA | pTyr | Yes | |||||
| FCP | pSer | Yes | |||||||
| NagD | pTyr, pSer | Yes | |||||||
| MTDP | MTDP | PPP | pSer/pThr | Yes | |||||
| PAP | ? | Yes | |||||||
| PPM/PP2C | PPM/PP2C | PPM/PP2C | pSer/pThr | Yes | |||||
| AP | AP | AP | pTyr, perhaps pSer/pThr | Yes | |||||
| HP | HP | HP, branch 1 | pTyr, pSer/pThr | Yes | |||||
| HP, branch 2 | pTyr | Yes | |||||||
| PHP | PHP | PHP | pHis | Yes | |||||
| RTR1 | RTR1 | RTR1 | pSer | Yes |
Abbreviations: CC1, Cysteine-based Class I; CC2, Cysteine-based Class II; CC3, Cysteine-based Class III; MTDP, MeTallo-Dependent Phosphatase; PAP, Purple Acid Phosphatase; AP, Alkaline Phosphatase; HP, Histidine Phosphatase.
