Difference between revisions of "Phosphatase classification"
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Phosphatases were first clustered by sequence similarity in the phosphatase domain, and additional information from domains outside of the catalytic domain, from evolutionary conservation, and from known functions was added. The result is a hybrid classification, in which no criterion is universally satisfied, but aims to be of practical use to a range of phosphatase interests. The classification grows as new phosphatomes are sequenced. | Phosphatases were first clustered by sequence similarity in the phosphatase domain, and additional information from domains outside of the catalytic domain, from evolutionary conservation, and from known functions was added. The result is a hybrid classification, in which no criterion is universally satisfied, but aims to be of practical use to a range of phosphatase interests. The classification grows as new phosphatomes are sequenced. | ||
Revision as of 21:52, 8 March 2016
Phosphatases were first clustered by sequence similarity in the phosphatase domain, and additional information from domains outside of the catalytic domain, from evolutionary conservation, and from known functions was added. The result is a hybrid classification, in which no criterion is universally satisfied, but aims to be of practical use to a range of phosphatase interests. The classification grows as new phosphatomes are sequenced.
Classification Chart of Protein Phosphatases
| Fold | Superfamily | Family | Substrate | Present in human |
|---|---|---|---|---|
| CC1 | CC1 | PTP | pTyr | Yes |
| DSP | pTyr, pSer/pThr, small molecule | Yes | ||
| PTEN | lipid | Yes | ||
| Myotubularin | lipid | Yes | ||
| SAC | lipid | Yes | ||
| Paladin | inactive | Yes | ||
| OCA | ? | |||
| CC2 | CC2 | LMWPTP | pTyr | Yes |
| SSU72 | pSer | Yes | ||
| ArsC | Arsenate | |||
| CC3 | CC3 | CDC25 | pTyr, pThr | Yes |
| HAD | HAD | EYA | pTyr | Yes |
| FCP | pSer | Yes | ||
| NagD | pTyr, pSer | Yes | ||
| PPPL | PPPL | PPP | pSer/pThr | Yes |
| PAP | ? | Yes | ||
| PPM | PPM | PPM | pSer/pThr | Yes |
| AP | AP | AP | pTyr, perhaps pSer/pThr | Yes |
| HP | HP | HP1 | pTyr, pSer/pThr | Yes |
| HP2 | pTyr, small molecules | Yes | ||
| PHP | PHP | PHP | pHis | Yes |
| RTR1 | RTR1 | RTR1 | pSer of CTD repeats | Yes |
Synonymns: CC3, Rhodanese; PPM, PP2C.
Abbreviations: CC1, Cysteine-based Class I; CC2, Cysteine-based Class II; CC3, Cysteine-based Class III; MTDP, MeTallo-Dependent Phosphatase; PAP, Purple Acid Phosphatase; AP, Alkaline Phosphatase; HP, Histidine Phosphatase; HP1, Histidine Phosphatase, branch 1; HP2, Histidine Phosphatase, branch 2; CTD, RNA Poly II C-Terminal Domain.
Notes of classification
Phosphorylation of RNA polymerase II C-terminal domain
Both FCPs of HAD fold and SSU72 of CC2 fold can dephosphorylate CTD.
PTPLA is a dubious phosphatase
Notes on the PTPLA/PTP-like family that was claimed to be a phosphatase, but probably is not.
Non-protein phosphatases
Some phosphatases only dephosphorylate non-protein substrates, as far as known.
Other Classification Schemes
Technical notes
- What are the single-gene subfamilies in nine genomes. We keep them because they are found in at least two genera, although they are not found in the other genome among the nine genomes: dicty, budding yeast, monosiga, sponge, nematostella, C. elegans, Drosophila, sea urchin, and human.
